Atg8: an autophagy-related ubiquitin-like protein family
نویسندگان
چکیده
منابع مشابه
The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy.
Autophagy is an evolutionarily-conserved catabolic process initiated by the engulfment of cytosolic components in a crescent-shaped structure, called the phagophore, that expands and fuses to form a closed double-membrane vesicle, the autophagosome. Autophagosomes are subsequently targeted to the lysosome/vacuole with which they fuse to degrade their content. The formation of the autophagosome ...
متن کاملThe autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation.
In autophagy, a cup-shaped membrane called the isolation membrane is formed, expanded, and sealed to complete a double membrane-bound vesicle called the autophagosome that encapsulates cellular constituents to be transported to and degraded in the lysosome/vacuole. The formation of the autophagosome requires autophagy-related (Atg) proteins. Atg8 is a ubiquitin-like protein that localizes to th...
متن کاملBinding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.
Autophagy is an intracellular trafficking pathway sequestering cytoplasm and delivering excess and damaged cargo to the vacuole for degradation. The Atg1/ULK1 kinase is an essential component of the core autophagy machinery possibly activated by binding to Atg13 upon starvation. Indeed, we found that Atg13 directly binds Atg1, and specific Atg13 mutations abolishing this interaction interfere w...
متن کاملAtg8 Family Proteins — Autophagy and Beyond
In eukaryotic cells, macroautophagy is now recognised as the most important mechanism for degradation of long-lived proteins and complete organelles, thus enabling cells to sustain their function under conditions of stress, such as nutrient deprivation, hypoxia or the presence of intracellular pathogens (for recent reviews, see [1,2]). While the core machinery is conserved in all eukaroytes [3]...
متن کاملAutophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family
Selective ubiquitin-dependent autophagy plays a pivotal role in the elimination of protein aggregates, assemblies, or organelles and counteracts the cytotoxicity of proteins linked to neurodegenerative diseases. Following substrate ubiquitylation, the cargo is delivered to autophagosomes involving adaptors like human p62 that bind ubiquitin and the autophagosomal ubiquitin-like protein Atg8/LC3...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2011
ISSN: 1465-6906
DOI: 10.1186/gb-2011-12-7-226